![]() ![]() ![]() Hippocampus and white matter HDAC expression negatively correlates with emotion regulation skills (n 23).Īge and sex are associated with HDAC expression in vivo, which could drive age- and sex-related transcriptional changes and impact human behavior. There are also sex-specific in vivo HDAC expression differences in brain regions associated with emotion and memory, including the amygdala and hippocampus. Relative HDAC expression increases with age in cerebral white matter, and correlates with age-associated disruptions in white matter microstructure.Ī post mortem study confirmed that HDAC1 and HDAC2 paralogs are elevated in white matter tissue from elderly donors. Here, we measure in vivo expression of the epigenetic enzymes, histone deacetylases (HDACs), across healthy human aging and between sexes using 11CMartinostat positron emission tomography (PET) neuroimaging (n 41). Neuroepigenetic pathways regulate gene transcription in the brain. Zrcher Harvard Medical School Mary Catanese Athinoula A. Socialplay V2.0.0 Download Available Content. ![]()
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